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Product Details
A15738
| Applications | Tested Dilution | Publications |
|---|---|---|
Flow Cytometry (Flow) |
20 µL/1x10^6 cells | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
MEM-180 |
Immunogen |
PHA-activated peripheral blood cells |
Conjugate |
FITC
|
Excitation/Emission Max |
498/517 nm
View spectra
|
Form |
Liquid |
Purification |
Size-exclusion chromatography |
Storage buffer |
PBS, pH 7.4, with 0.2% BSA |
Contains |
15mM sodium azide |
Storage conditions |
4° C, store in dark |
RRID |
AB_2534518 |
Target Information
CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adhesion G protein-coupled receptor E5; Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta; CD97; CD97 molecule; Leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation
Gene Aliases: ADGRE5; CD97; TM7LN1
UniProt ID: (Human) P48960
Entrez Gene ID: (Human) 976
Molecular Function:
G-protein coupled receptor
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