Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
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Protein Aliases: CENP-H; CENPH; Centromere protein H; Interphase centromere complex protein 35; kinetochore protein CENP-H
Gene Aliases: CENPH; ICEN35
UniProt ID: (Human) Q9H3R5
Entrez Gene ID: (Human) 64946