Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-30106 detects CFLAR from human samples.
PA1-30106 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-30106 immunogen is: Synthetic peptide corresponding to the C-terminus of human I-FLICE.
FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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