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CPEB4 Antibody (PA5-25538) in IHC (P)
Immunohistochemistry analysis of CPEB4 in formalin fixed and paraffin embedded human lung carcinoma. Samples were incubated with CPEB4 polyclonal antibody (Product # PA5-25538) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25538
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 109-137 amino acids from the N-terminal region of human CPEB4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2543038
Target Information
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CPE-binding protein 4; CPE-BP4; Cytoplasmic polyadenylation element-binding protein 4
Gene Aliases: CPE-BP4; Cpeb-4; CPEB4; hCPEB-4; KIAA1673; mCPEB-4
UniProt ID: (Human) Q17RY0, (Mouse) Q7TN98
Entrez Gene ID: (Human) 80315, (Mouse) 67579
response to ischemia
translation
ionotropic glutamate receptor signaling pathway
cellular response to decreased oxygen levels
cellular response to glucose starvation
negative regulation of neuron apoptotic process
cellular response to amino acid stimulus
negative regulation of cytoplasmic translation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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