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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified recombinant fragment of human CRK expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15891 targets CRK in FACS, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15891 immunogen is purified recombinant fragment of human CRK expressed in E. Coli. .
MA5-15891 detects CRK which has a predicted molecular weight of approximately 42kDa.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRKII, p38, adapter molecule crk; CT-10 related kinase 3; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein
c-Crk; CRK; Crk-I; Crk-II; Crk-III; Crk3; CRKII; CrkIII; Crko; p38