This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
MA5-14744 targets C Reactive Protein in ELISA, IP, and RIA applications and shows reactivity with Human samples.
The MA5-14744 immunogen is purified human plasma CRP.
MA5-14744 detects C Reactive Protein which has a predicted molecular weight of approximately 23 kDa.
Product MA514744 is a smaller package size of MIC0501 (formerly sold as a Seradyn product).
CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c reactive; C-reactive protein; C-reactive protein(1-205); CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; pentraxin 1; RP11-419N10.4
Gene Aliases: CRP; PTX1
UniProt ID: (Human) P02741
Entrez Gene ID: (Human) 1401