Reconstitute at 0.5 mg/mL in sterile PBS.
CXCL12, Stromal cell derived factor beta 1 (SDF1) is a 70 amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. This member of the intercrine alpha (chemokine CxC) family is a chemoattractant active on T lymphocytes, monocytes, but not neutrophils. Targeted deletion of SDF1 gene resulted in defects of B cell lymphopoiesis and bone marrow myelopoiesis in mice. SDF1 has been shown to be chemotactic for lymphocytes. In addition, SDF1 was recently reported to be a ligand for CXCR4 (LESTR/fusin) and a co receptor for HIV1 entry into T cells (SDF1 binding to CXCR4 inhibits HIV1 entry).
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Protein Aliases: C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; SDF-1; SDF-1-alpha(3-67); SDF-1-beta(3-72); SDF1; SDF1A; SDF1B; Stromal cell-derived factor 1
Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1
UniProt ID: (Human) P48061
Entrez Gene ID: (Human) 6387