|Flow Cytometry (Flow)||10 µl for 10^6 PBMC|
|Inhibition Assays (IA)||0.1 - 0.3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Human CXCR1 transfected NSO mouse myeloma cells.|
|Storage buffer||PBS with 5% trehalose|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-24668 detects CXCR1 from human samples. Human CXCR1 reacts with CXCR1 transfected cells and not with the parent cell line by flow cytometry. Thw antibody shows no cross-reactivity with human CXCR2.
MA1-24668 has been successfully used in inhibition assay and FACS procedures.
The MA1-24668 immunogen is human CXCR1 transfected NSO mouse myeloma cells.
Endotoxin level is less than 10 ng per mg antibody as determined by the LAL method.
Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The alpha and beta families, with four cysteine residues, are the largest and best characterized. In the alpha family, one amino acid separates the first two cysteine residues (CXC); in the beta family the two cysteine residues (CC) are adjacent to each other. The alpha chemokines that contain the N-terminal Glu-Leu-Arg amino acid sequence (ELR-motif) are chemotactic for neutrophils (such as IL8), while those that do not, act on lymphocytes (such as IP10 and MIG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C; C-C-CKR-1; C-X-C chemokine receptor type 1; CD128; CD181; CDw128a; chemokine (C-X-C motif) receptor 1; CKR-1; CMKAR1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8 Receptor alpha; IL-8 receptor type 1; IL-8R A; IL-RA; IL8R1; IL8RA; IL8RBA; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A
Gene Aliases: C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXCR1; IL8R1; IL8RA; IL8RBA
UniProt ID: (Human) P25024
Entrez Gene ID: (Human) 3577
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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