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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide corresponding to the N-terminal residues 1-19 of human CXCR2.|
|Storage buffer||PBS, pH 7.2|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is human isolated neutrophils.
CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-X-C chemokine receptor type 2; CD182; CD182 antigen; CDw128b; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; high affinity interleukin-8 receptor B; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; Il-8rb; IL8R2; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Signal transduction Cell surface receptor mediated signal transduction G-protein mediated signaling Immunity and defense Granulocyte-mediated immunity Cytokine/chemokine mediated immunity Cell structure and motility Cell motility