|Tested species reactivity||Human, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to residues T E E M G S G D Y D S M K E P C F R E E N A N F N K C of human CXCR4.|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M potassium phosphate, pH 7.2, with 0.14M NaCl|
|Storage Conditions||-20°C or -80°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:300|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21626 detects CXCR4 in human and rat samples.
PA1-21626 has been successfully used in ELISA, immunohistochemistry (FFPE), and Western blot procedures. Suggested positive controls for this product are human peripheral blood cells or sections of human spleen cells.
The PA1-21626 immunogen is a synthetic peptide corresponding to residues T E E M G S G D Y D S M K E P C F R E E N A N F N K C of human CXCR4.
The C-X-C chemokines contain a pair of cysteine residues separated by a single amino acid. These chemokines function as chemo-attractants for neutrophils. Receptors for the C-X-C family include IL-8RA (also known as CXCR-1), IL-8RB (also called CXCR-2), CXCR-3 and fusin (LESTR or CXCR-4). Fusin has been identified as the major co-receptor for HTLV and HIV-1; and SDF-1 has been shown to inhibit HIV-1 infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.