This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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MA5-11626 targets Caldesmon HMW in IHC (P), IF and WB applications and shows reactivity with human and mouse samples.
The MA5-11626 immunogen is crude human uterus extract.
Caldesmon is a developmentally regulated protein involved in smooth muscle and non muscle contraction. Two closely related variants of human caldesmon have been identified which differ in their electrophorectic mobility and cellular distribution. The h caldesmon variant (120 - 150 kDa) is predominantly expressed in smooth muscle whereas l caldesmon (70 - 80 kDa) is found in non-muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle.
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Protein Aliases: Caldesmon; CDM; h-caldesmon; L-caldesmon; MGC21352; Non-muscle caldesmon; OTTHUMP00000207950; OTTHUMP00000207953; OTTHUMP00000207954; OTTHUMP00000207955; OTTHUMP00000214473; testis secretory sperm-binding protein Li 227n
Gene Aliases: 4833423D12Rik; AI195384; AV071549; AW536160; C920027I18Rik; CAD; CALD1; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Molecular Function: non-motor actin binding protein