Immunogen sequence: FWLPLLEKVY AKVHGSYEHL WAGQVADALV DLTGGLAERW NLKGVAGSGG QQDRPGRWEH RTCRQLLHLK DQCLISCCVL SPRAGARELG EFHAFIVSDL
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 82%.
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium-activated neutral proteinase 10; Calpain-10; calpain-like protease CAPN10; CANP 10; CANP10; NIDDM1
Gene Aliases: CANP10; CAPN10; KIAA1845; NIDDM1
UniProt ID: (Human) Q9HC96
Entrez Gene ID: (Human) 11132