The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and m-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, m-calpain is active at micromolar (mM) concentrations of Ca++. In addition to the ubiquitously expressed m- and m- calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
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Protein Aliases: Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit 2; calcium-dependent protease, small subunit; calpain 4; calpain 4, small subunit (30K); Calpain regulatory subunit; Calpain small subunit 1; Calpain small subunit 2; calpain, small polypeptide; calpain, small subunit 1; calpain, small subunit 2; CANP small subunit; CDPS; CSS1; CSS2
Gene Aliases: 2310005G05Rik; 30K-2; CALPAIN4; CANP; CANPS; Capa-4; Capa4; CAPN4; CAPNS; CAPNS1; CAPNS2; CDPS; CSS1; D7Ertd146e