The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
CPN is a tetrameric complex consisting of two identical regulatory subunits (CPN reg) and two identical catalytic subunits (CPN cat). CPN reg is a member of the leucine-rich repeat family of proteins and CPN cat is a member of the regulatory B-type carboxypeptidase group. Carboxypeptidase E (CPE) is important for removing any remaining C-terminal Arg or Lys after initial endoprotease cleavage during prohormone processing. CPE is also crucial in proinsulin processing, and required for normal-sized photoreceptor synaptic terminal and normal signal transmission to the inner retina.
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Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE; Cobalt stimulated chromaffin granule carboxypeptidase; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Cph 1; Cph1; Enkephalin convertase; Entephalin convertase; Insulin granule associated carboxypeptidase; insulin granule-associated carboxypeptidase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: CPE; CPH; Cph-1; Cph1; fat; R74677