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Product Details
602-050
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1-1 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
2-10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide corresponding to the epitope DNYGS without phosphorylation of human beta-catenin |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with proprietary stabilizer |
Contains |
0.01% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
Positive control: Human breast carcinoma
Cellular location: Cytoplasm, Nucleus, Cell membrane.
Target Information
Delta 1 Catenin is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin-associated Src substrate; Cadherin-associated Src substrate (CAS); CAS; Catenin (cadherin associated protein) delta 1; catenin (cadherin-associated protein), delta 1; Catenin delta-1; catenin src; p120 catenin; P120 CTN; P120 p120; P120 P120CTN; p120(cas); p120(ctn); p120-catenin
Gene Aliases: AA409437; AU019353; CAS; Catns; CTNND; CTNND1; KIAA0384; mKIAA0384; P120; p120(CAS); p120(CTN); P120CAS; P120CTN
UniProt ID: (Human) O60716, (Mouse) P30999
Entrez Gene ID: (Human) 1500, (Mouse) 12388, (Rat) 311163
Molecular Function:
intermediate filament binding protein
transcription, DNA-templated
regulation of transcription, DNA-templated
cell adhesion
brain development
Wnt signaling pathway
single organismal cell-cell adhesion
adherens junction organization
negative regulation of canonical Wnt signaling pathway
morphogenesis of a polarized epithelium
salivary gland morphogenesis
keratinocyte differentiation
epithelial cell differentiation involved in salivary gland development
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