MA1-40241 detects Caveolin-1 from rat samples.
MA1-40241 recognizes caveolin-1? as well as caveolin-1?, which are present in many tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat. MA1-40241 can be used to immuno-isolate caveolae.
MA1-40241 has been successfully used in immunofluorescence, immunoprecipitation and Western blot applications.
The MA1-40241 immunogen is rat caveolin.
Positive control: Adipocytes (3T3-L1 adipocytes); Negative control: Cytoplasmic extracts of adipocytes.
Caveolin-1 or CAV1 is a 22 kDa scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Caveolin cycles between the plasma membrane and intracellular compartments via the endocytotic pathway. Caveolin is involved in the rapid intracellular transport of newly synthesized cholesterol from the ER directly to the caveolae. Caveolin plays an important role in multiple signaling pathways, molecular transport and cellular proliferation and differentiation. Caveolin binds to endothelial nitric oxide synthase leading to enzyme inhibition. Furthermore caveolin is a candidate tumor suppressor gene in many tumors. The specific functions of caveolin-1/caveolae are highly cell and context dependent. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
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Protein Aliases: CAV1; caveolin caveolae protein 22 kDa; caveolin-1
Gene Aliases: Cav
Entrez Gene ID: (Rat) 25404