MA1-40241 detects Caveolin-1 from rat samples.
MA1-40241 recognizes caveolin-1? as well as caveolin-1?, which are present in many tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat. MA1-40241 can be used to immuno-isolate caveolae.
MA1-40241 has been successfully used in immunofluorescence, immunoprecipitation and Western blot applications.
The MA1-40241 immunogen is rat caveolin.
Positive control: Adipocytes (3T3-L1 adipocytes); Negative control: Cytoplasmic extracts of adipocytes.
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
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Protein Aliases: caveolae; caveolin caveolae protein 22 kDa; caveolin-1; HGNC:1527; OTTHUMP00000196475
Gene Aliases: Cav
Entrez Gene ID: (Rat) 25404