|ELISA (ELISA)||Assay dependent.|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-20|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Purified collagen type I extracted from human skin.|
|Storage conditions||4° C|
Reconstitute with 1 ml of distilled water and add preservative if preferred.
Type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-1 type I collagen; alpha1(I) procollagen; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; pro-alpha-1 collagen type 1; type I proalpha 1; type I procollagen alpha 1 chain
Gene Aliases: COL1A1; EDSC; OI1; OI2; OI3; OI4
UniProt ID: (Human) P02452
Entrez Gene ID: (Human) 1277
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