Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
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Protein Aliases: axonal-associated cell adhesion molecule; BIG-1; BIG-2; brain-derived immunoglobulin superfamily molecule; Brain-derived immunoglobulin superfamily protein 1; Brain-derived immunoglobulin superfamily protein 2; contactin 3 (plasmacytoma associated); Contactin-3; Contactin-4; Contactin-5; Contactin-6; hNB-2; hNB-3; mNB-3; neural adhesion molecule; neural cell adhesion protein BIG-2; Neural recognition molecule NB-2; Neural recognition molecule NB-3; Plasmacytoma-associated neuronal glycoprotein; Plasmacytoma-associated neuronal glycoprotein (neural cell adhesion molecule BIG-1)
Gene Aliases: 6720426O10Rik; 9630050B05; A830025P08Rik; AXCAM; BIG-1; BIG-2; CNTN3; CNTN4; CNTN5; CNTN6; Gm507; HNB-2s; KIAA1496; Kiaa3024; NB-2; NB-3; NB3; PANG; PCS
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor