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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Marsupial, Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein encoding NBF2 domain of human CFTR|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:12.5-25|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11768 targets Cystic Fibrosis Transmembrane Regulator in IF, IHC (P), IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11768 immunogen is recombinant protein encoding NBF2 domain of human CFTR.
CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CFTR is restricted to a small population of high expresser cells that provide a forskolin-sensitive transepithelial Cl- conductance in the proximal colon of the possum, Trichosurus vulpecula.
MA5-11768 was used in western blot to study the expression of CFTR in the possum small intestine
|Fan S,Harfoot N,Bartolo RC,Butt AG||The Journal of experimental biology (215:1218)||2012|
Molecular and functional characterization of the cystic fibrosis transmembrane conductance regulator from the Australian common brushtail possum, Trichosurus vulpecula.
MA5-11768 was used in western blot to characterize cystic fibrosis transmembrane conductance regulator from the Australian common brushtail possum
|Demmers KJ,Carter D,Fan S,Mao P,Maqbool NJ,McLeod BJ,Bartolo R,Butt AG||Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (180:545)||2010|
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets.
MA5-11768 was used in immunocytochemistry to characterize multipotent stem/progenitor cells in peribiliary glands of human biliary tree
|Cardinale V,Wang Y,Carpino G,Cui CB,Gatto M,Rossi M,Berloco PB,Cantafora A,Wauthier E,Furth ME,Inverardi L,Dominguez-Bendala J,Ricordi C,Gerber D,Gaudio E,Alvaro D,Reid L||Hepatology (Baltimore, Md.) (54:2159)||2011|
Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.
MA5-11768 was used in immunocytochemistry to investigate the mechanism of cholangiocyte proliferation induced by H1 histamine receptor activation
|Francis H,Glaser S,Demorrow S,Gaudio E,Ueno Y,Venter J,Dostal D,Onori P,Franchitto A,Marzioni M,Vaculin S,Vaculin B,Katki K,Stutes M,Savage J,Alpini G||American journal of physiology. Cell physiology (295:C499)||2008|
Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
MA5-11768 was used in immunohistochemistry to study the role of lumenal adenosine in modulating the secretion of bicarbonate in rat duodenum and the mechanism involved
|Ham M,Mizumori M,Watanabe C,Wang JH,Inoue T,Nakano T,Guth PH,Engel E,Kaunitz JD,Akiba Y||The Journal of pharmacology and experimental therapeutics (335:607)||2010|
Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the human brain.
MA5-11768 was used in immunohistochemistry to study cystic fibrosis transmembrane conductance regulator in human central nerve system
|Guo Y,Su M,McNutt MA,Gu J||The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (57:1113)||2009|
Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium.
MA5-11768 was used in immunohistochemistry to study the cellular constituents of the mouse intrahepatic biliary epithelium
|Glaser SS,Gaudio E,Rao A,Pierce LM,Onori P,Franchitto A,Francis HL,Dostal DE,Venter JK,DeMorrow S,Mancinelli R,Carpino G,Alvaro D,Kopriva SE,Savage JM,Alpini GD||Laboratory investigation; a journal of technical methods and pathology (89:456)||2009|
Expression of cystic fibrosis transmembrane conductance regulator in ganglion cells of the hearts.
MA5-11768 was used in immunohistochemistry to examine the involvement of cystic fibrosis transmembrane conductance regulator in the function of ganglion cells
|Pan P,Guo Y,Gu J||Neuroscience letters (441:35)||2008|
ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
ABC35; ABCC7; AW495489; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; RGD1561193; TNR-CFTR