MA5-14425 targets Cytokeratin 8 in IHC (P) and IP applications and shows reactivity with Human samples.
The MA5-14425 immunogen is keratin preparation from a human carcinoma.
Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.
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Protein Aliases: CK-8; cytokeratin 8; Cytokeratin-8; K8; keratin; keratin 8, type II; Keratin, type II cytoskeletal 8; Keratin-8; type II cytoskeletal 8; Type-II keratin Kb8
Gene Aliases: CARD2; CK-8; CK8; CYK8; K2C8; K8; KO; KRT8
UniProt ID: (Human) P05787
Entrez Gene ID: (Human) 3856