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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:8,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
1E9B3 |
Immunogen |
D2HGDH Fusion Protein Ag5036 (1-286 aa encoded by BC036604) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MLPRRPLAW PAWLLRGAPG AAGSWGRPVG PLARRGCCSA PGTPEVPLTR ERYPVQRLPF STVSKQDLAA FERIVPGGVV TDPEALQAPN VDWLRTLRGC SKVLLRPRTS EEVSHILRHC HERNLAVNPQ GGNTGMVGGS VPVFDEIILS TARMNRVLSF HSVSGILVCQ AGCVLEELSR YVEERDFIMP LDLGAKGSCH IGGNVATNAG GLRFLRYGSL HGTVLGLEVV LADGTVLDCL TSLRKDNTGY DLKQLFIGSE GTLGIITTVS ILCPPKPRAV NVAFLGC (1-286 aa encoded by BC036604)
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D-2-hydroxyglutarate dehydrogenase, mitochondrial; FLJ42195; MGC25181
Gene Aliases: AA408776; AA408778; AI325464; D2HGD; D2HGDH
UniProt ID: (Human) Q8N465, (Mouse) Q8CIM3
Entrez Gene ID: (Human) 728294, (Mouse) 98314
Molecular Function:
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
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