Immunogen sequence: SGGSQLLEHP SRKIFRKSRI SEEDDRSELD DNNTMEEVKS DSTENSNSRD TGLSQPRRDS KGDSQEDSKE NLSQEESQNV DGPSSESSQE ANLSSQENSS ESQEEVVSES RGDNPDPTTS YVEDQEDSDS SEEDSSHTLS HSKSESREEQ ADSESSESLN FSEESPESPE DENSSSQEGL QSHSSSAESQ SEESHSEEDD SDSQDSSRSK EDSNSTESKS SSEEDGQLKN IEIESRKLTV DAYHNKPIGD QDDNDCQDGY; Positive Samples: U-937, U-251MG, Mouse brain; Cellular Location: Cytoplasm, Nucleus, extracellular matrix, extracellular space
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: AG1; Dentin matrix acidic phosphoprotein 1; dentin matrix protein 1; DMP 1; DMP-1; MGC130441; serine rich acidic phosphoprotein
Gene Aliases: ARHP; ARHR; AV020965; Dmp; DMP-1; DMP1; PP