Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 4
Immunogen sequence: SGGSQLLEHP SRKIFRKSRI SEEDDRSELD DNNTMEEVKS DSTENSNSRD TGLSQPRRDS KGDSQEDSKE NLSQEESQNV DGPSSESSQE ANLSSQENSS ESQEEVVSES RGDNPDPTTS YVEDQEDSDS SEEDSSHTLS HSKSESREEQ ADSESSESLN FSEESPESPE DENSSSQEGL QSHSSSAESQ SEESHSEEDD SDSQDSSRSK EDSNSTESKS SSEEDGQLKN IEIESRKLTV DAYHNKPIGD QDDNDCQDGY; Positive Samples: U-937, U-251MG, Mouse brain; Cellular Location: Cytoplasm, Nucleus, extracellular matrix, extracellular space
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support