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A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
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Protein Aliases: Dnm1p/Vps1p-like protein; DVLP; Dymple; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV 11; DYNIV-11; EC 184.108.40.206; FLJ41912; HdynIV; VPS1
Gene Aliases: DLP1; DNM1L; DRP1; DVLP; DYMPLE; EMPF; HDYNIV
UniProt ID: (Human) O00429
Entrez Gene ID: (Human) 10059
Molecular Function: membrane traffic protein