PA1-20222 detects Drebrin in rat and human samples. This antibody is expected to cross-react with mouse (100%) and chicken (85%) due to sequence homology.
PA1-20222 has been successfully used in Western blot procedures.
The PA1-20222 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues 22-42 of human Drebrin.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D0S117E; Developmentally-regulated brain protein; DKFZp434D064; Drebrin; drebrin A; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1; Drba