This antibody binds to both dynorphin A 1-17 and 1-8 but not with other big dynorphin cleavage products such as dynorphin B, also known as rimorphin.
This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase. Overnight incubation with primary antibody is recommended.
The immunogen used to produce PA1-84557 is from Dynorphin A 1-17: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln (porcine).
Rabbit anti Human dynorphin A antibody recognizes the opioid peptide dynorphin A (Fischli et al. 1982), a cleavage product of big dynorphin, itself derived from the precursor pro-encephalin-B, also known as preprodynorphin.
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-neoendorphin; Beta-neoendorphin; Beta-neoendorphin-dynorphin; Big Dyn; Big dynorphin; Dyn-A17; Dyn-B; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8); Dynorphin B; Dynorphin B(1-13); Dynorphin B-29; Leu-enkephalin; Leumorphin; MGC26418; neoendorphin-dynorphin-enkephalin prepropeptide; Preprodynorphin; preproenkephalin B; proenkephalin B; Proenkephalin-B; Rimorphin; unnamed protein product
Gene Aliases: ADCA; PDYN; PENKB; SCA23
UniProt ID: (Human) P01213