Invitrogen

EGR1/EGR2 Polyclonal Antibody

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EGR1/EGR2 Antibody in Western Blot (WB) — Western blot analysis of EGR1 + EGR2 in extracts from HeLa and Jurkat cells using an EGR1 + EGR2 polyclonal antibody (Product # PA5-38588).

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide derived from the internal region of human EGR1/2

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2555187

Target Information

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT225; AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 1; Early growth response protein 2; EGR-1; EGR-2; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); Krox-24 nuclear protein; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-20; Zinc finger protein Krox-24

Gene Aliases: A530045N19Rik; AT225; AT591; CMT1D; CMT4E; egr; Egr-1; Egr-2; EGR1; EGR2; ETR103; G0S30; Krox-1; Krox-20; KROX-24; KROX20; KROX24; Ngf1; NGF1-A; NGF1-B; Ngfi; NGFI-A; NGFIA; TIS8; Zenk; Zfp-25; Zfp-6; ZIF-268; Zif268; ZNF225

UniProt ID: (Human) P18146, (Human) P11161, (Rat) P08154, (Mouse) P08046, (Mouse) P08152, (Rat) P51774

Entrez Gene ID: (Human) 1958, (Human) 1959, (Rat) 24330, (Mouse) 13653, (Mouse) 13654, (Rat) 114090

negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to glucose T cell differentiation BMP signaling pathway response to insulin regulation of protein sumoylation skeletal muscle cell differentiation regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway cellular response to gamma radiation cellular response to heparin cellular response to mycophenolic acid glomerular mesangial cell proliferation positive regulation of glomerular metanephric mesangial cell proliferation negative regulation of canonical Wnt signaling pathway protein export from nucleus brain development peripheral nervous system development learning or memory rhythmic behavior motor neuron axon guidance Schwann cell differentiation protein sumoylation facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification brain segmentation myelination fat cell differentiation regulation of neuronal synaptic plasticity cellular response to organic substance response to amphetamine regulation of transcription, DNA-templated circadian rhythm positive regulation of gene expression positive regulation of cell death response to nutrient levels response to follicle-stimulating hormone cellular response to insulin stimulus response to carbon monoxide response to gonadotropin cellular response to drug response to cocaine response to drug negative regulation of apoptotic process positive regulation of neuron apoptotic process response to ethanol regulation of long-term neuronal synaptic plasticity oligodendrocyte differentiation response to electrical stimulus long-term synaptic potentiation cellular response to antibiotic cellular response to mechanical stimulus cellular response to isoquinoline alkaloid cellular response to cAMP cellular response to growth factor stimulus cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus cellular response to hyperoxia cellular response to hypoxia response to norepinephrine transcription, DNA-templated rhombomere 3 development

Process(es)

transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone acetyltransferase binding sequence-specific DNA binding metal ion binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II activating transcription factor binding chromatin binding ligase activity ubiquitin protein ligase binding transcription regulatory region DNA binding HMG box domain binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding double-stranded DNA binding transcription factor binding nucleic acid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity