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Proteintech
EPHA4 Polyclonal Antibody
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Product Details
21875-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EPHA4 Fusion Protein Ag16233 (481-603 aa encoded by BC026327)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KDQNERSYR IVRTAARNTD IKGLNPLTSY VFHVRARTAA GYGDFSEPLE VTTNTVPSRI IGDGANSTVL LVSVSGSVVL VVILIAAFVI SRRRSKYSKA KQEADEEKHL NQGVRTYVDP FTYE (481-603 aa encoded by B C026327)
Target Information
EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EK8; epa4; EPH-like kinase 8; Ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; TYRO1 protein tyrosine kinase; Tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase receptor SEK-1; Tyrosine-protein kinase TYRO1; unnamed protein product
Gene Aliases: 2900005C20Rik; AI385584; Cek8; EK8; EPHA4; HEK8; rb; RGD1560587; SEK; Sek1; TYRO1
UniProt ID: (Human) P54764, (Mouse) Q03137
Entrez Gene ID: (Human) 2043, (Rat) 316539, (Mouse) 13838
nucleotide binding
beta-amyloid binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
PH domain binding
identical protein binding
ephrin receptor binding
DH domain binding
protein tyrosine kinase binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
deadenylation-dependent decapping of nuclear-transcribed mRNA
cell adhesion
negative regulation of cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
adult walking behavior
motor neuron axon guidance
positive regulation of cell proliferation
glial cell migration
negative regulation of epithelial to mesenchymal transition
negative regulation of neuron projection development
negative regulation of translation
corticospinal tract morphogenesis
positive regulation of cell migration
negative regulation of cell migration
adherens junction organization
regulation of GTPase activity
negative regulation of neuron apoptotic process
positive regulation of cell adhesion
negative regulation of translational initiation
positive regulation of JNK cascade
ephrin receptor signaling pathway
negative regulation of axon regeneration
regulation of astrocyte differentiation
regulation of axonogenesis
positive regulation of dendrite morphogenesis
protein stabilization
innervation
regulation of dendritic spine morphogenesis
negative regulation of ERK1 and ERK2 cascade
nephric duct morphogenesis
cochlea development
fasciculation of sensory neuron axon
fasciculation of motor neuron axon
neuron projection guidance
synapse pruning
neuron projection fasciculation
membraneless organelle assembly
negative regulation of cellular response to hypoxia
negative regulation of long-term synaptic potentiation
positive regulation of beta-amyloid formation
positive regulation of intracellular signal transduction
positive regulation of amyloid precursor protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
cellular response to beta-amyloid
regulation of modification of synaptic structure
regulation of synapse pruning
peptidyl-tyrosine phosphorylation
positive regulation of JUN kinase activity
protein autophosphorylation
positive regulation of Rho guanyl-nucleotide exchange factor activity
protein phosphorylation
multicellular organism development
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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