Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
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Protein Aliases: CAPB; Cek5; DRT; EK5; embryo kinase 5 protein CEK5; EPH receptor B2; EPH-like kinase 5; EPHB2; EphB2/CTF1; EphB2/CTF2; Ephrin type-B receptor 2; EPHT3; EPTH3; ETECK; Hek5; Nuk; PCBC; Protein-tyrosine kinase HEK5; Tyro5
Gene Aliases: CEK5; EPHB2
UniProt ID: (Chicken) P28693
Entrez Gene ID: (Chicken) 396513