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Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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PA1-316 detects human and mouse ERR3 from transfected cells and shows no cross-reactivity to ERR1.
PA1-316 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~54 kDa protein representing ERR1 from COS-7 transfected cells. This antibody is not suitable for 293T cells in Western blot analysis.
PA1-316 immunogen is a synthetic peptide corresponding to residues D(401) Y E A G Q H M E D P R R(413) of human ERR3. This sequence is completely conserved between human, mouse and rat. This immunizing peptide (PEP-232) can be used for neutralization and control experiments.
Estrogen-related receptor gamma (ERRG, ERR3, NR3B3) is an orphan member of the nuclear hormone receptor superfamily. ERRG acts as a transcription activator in the absence of a bound ligand. It binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. ERRG also induces the expression of PERM1 in the skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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