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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human FAK expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15643 targets FAK in WB applications and shows reactivity with Human samples.
The MA5-15643 immunogen is purified recombinant fragment of human FAK expressed in E. Coli.
MA5-15643 detects FAK which has a predicted molecular weight of approximately 119kDa.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase-related nonkinase; FRNK; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; PTK2; PTK2 protein tyrosine kinase 2
FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71; PTK2