Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: FLANCMNRHV HVKDDFVRSV SETQNIESQK IHSSRLSDIT SSNMQICGFK STVPHFTEEE KYQKLLSENK IRDEQPKHQP D
Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 50%.
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: family with sequence similarity 35, member A; Protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; Shield complex subunit 2; Shieldin complex subunit 2
Gene Aliases: bA163M19.1; FAM35A; FAM35A1; RINN2; SHLD2
UniProt ID: (Human) Q86V20
Entrez Gene ID: (Human) 54537
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support