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Immunogen sequence: MAEPGEGLP EEVLALIFRH LSLRDRAAAA RVCRAWAAAA TCSAVWHDTK ISCECELEGM LPPYLSACLD HIHNLRLEFE PSRKPSRRAA IELLMVLAGR APGLRGLRLE CRGEKPLFDA GRDVLEAVHA VCGAASQLRH LDLRRLSFTL DDALVLQAAR SCPELHSLFL DNSTLVGSVG PGSVLELLEA CPRLRALGLH LASLSHAILE ALAAPDRAPF ALLALRCACP EDARASPLPN EAWVALRRRH PGLAVELELE PALPAESVTR VLQPAVPVAA LRLNLSGDTV GPVRFAAHHY AATLCALEVR AAASAELNAA LEELAARCAA LREVHCFCVV SHSVLDAFRA HCPRLRTYTL KLTREPHPWR PTLVA (1-374 aa encoded by BC014414)
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
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