Applications | Tested Dilution | Publications |
---|---|---|
Immunohistochemistry (IHC) |
1:100-1:200 | - |
Immunocytochemistry (ICC/IF) |
5-10 µg/mL | - |
ELISA (ELISA) |
1:10,000-1:50,000 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Anti-FGFR2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human FGFR2 conjugated to Keyhole Limpet Hemocyanin (KLH). |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
Contains |
0.01% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against human FGFR2. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse.
FGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bacteria-expressed kinase; BEK fibroblast growth factor receptor; CD332; FGF Receptor 2; FGFR-2; Fibroblast growth factor receptor 2; K-sam; Keratinocyte growth factor receptor; KGFR; protein tyrosine kinase, receptor like 14; Soluble KGFR
Gene Aliases: AU043015; AW556123; BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; Fgfr-2; Fgfr-7; FGFR2; Fgfr7; JWS; K-SAM; KGFR; KGFRTr; KSAM; svs; TK14; TK25
UniProt ID: (Human) P21802, (Mouse) P21803
Entrez Gene ID: (Human) 2263, (Mouse) 14183
Molecular Function:
transmembrane signal receptor
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