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PA1-31991 detects FGFR4 from human samples.
PA1-31991 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue), Western blot and ELISA applications. Detects a band of ~96 kDa. A suggested positive control for this product is THP-1 cell lysate.
The PA1-31991 immunogen is a synthetic peptide conjugated to KLH, corresponding to amino acids 39-56 of Human FGFR 4.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20° C or below, avoiding multiple freeze-thaw cycles.
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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