|Tested species reactivity||Human, Mouse|
|Published species reactivity||Rat, Human, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminus of human FZR protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
FZR is a 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. It has been shown that the over expression of fzr proteins increases natural killer cell-mediated cell death and as a result, suppresses tumor growth. The fzr protein is essential for cyclosome activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.
34-2000 was used in western blot to assess the role of the anaphase-promoting complex and Cdc20 in the primary cilium
|Wang W,Wu T,Kirschner MW||eLife (3:null)||2014|
|Not Applicable||Not Cited||
Degradation of cyclin A is regulated by acetylation.
34-2000 was used in western blot to investigate the effects of cyclin A acetylation on function
|Mateo F,Vidal-Laliena M,Canela N,Busino L,Martinez-Balbas MA,Pagano M,Agell N,Bachs O||Oncogene (28:2654)||2009|
|Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.||Almeida A,Bolaños JP,Moreno S||The Journal of neuroscience : the official journal of the Society for Neuroscience (25:8115)||2005|