|Immunohistochemistry (Paraffin) (IHC (P))||20 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 16 amino acid peptide from N-terminal extracellular domain of human FZD7 / Frizzled 7.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant, Bovine, Bat, Opossum (100%).
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Frizzled 7; frizzled 7, seven transmembrane spanning receptor; Frizzled family receptor 7; Frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FZD7; FzE3; HFz7
Gene Aliases: FZD7; FzE3
UniProt ID: (Human) O75084
Entrez Gene ID: (Human) 8324
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