Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
OPA1-04119 detects phospho GABA-B (pSer892) receptor R2 subunit in rat samples.
OPA1-04119 has been successfully used in Immunofluroescence and Western blot procedures. By Western blot, this antibody detects a ~110 kDa protein representing phospho GABA-B (pSer892) receptor R2 subunit in rat brain membrane fractions.
The OPA1-04119 immunizing peptide corresponds to the amino acid residues surrounding the phospho GABA-B (pSer892) receptor R2 subunit.
The multi-pass membrane protein, GABBR2, belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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