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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human GRIA2 (amino acids: 652-807) expressed in E. Coli.|
|Storage buffer||PBS with 0.5% proprietary stabilizer|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:200 - 1:400|
|Western Blot (WB)||1:500 - 1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17084 targets GRIA2 in FACS, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17084 immunogen is purified recombinant fragment of human GRIA2 (amino acids: 652-807) expressed in E. Coli.
MA5-17084 detects GRIA2 which has a predicted molecular weight of approximately 98.8kDa.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AMPA-selective glutamate receptor 2; gluR-2; gluR-B; glutamate receptor B flip isoform; glutamate receptor, ionotropic, AMPA 2
GluA2; GluR-K2; GLUR2; GLURB; GRIA2; HBGR2