Proteintech

GRIM19 Polyclonal Antibody

GRIM19 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GRIM19 Antibody (10986-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 10986-1-AP (GRIM19 antibody) at dilution of 1:50 (under 40x lens).

GRIM19 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10986-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GRIM19 Fusion Protein Ag1435 (1-144 aa encoded by BC009189)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAASKVKQD MPPPGGYGPI DYKRNLPRRG LSGYSMLAIG IGTLIYGHWS IMKWNRERRR LQIEDFEARI ALLPLLQAET DRRTLQMLRE NLEEEAIIMK DVPDWKVGES VFHTTRWVPP LIGELYGLRT TEEALHASHG FMWYT (1-144 aa encoded by BC009189)

Target Information

A novel gene associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 UTC 2022

Folate regulates RNA m⁵C modification and translation in neural stem cells.

BMC biology

Xu X,Johnson Z,Wang A,Padget RL,Smyth JW,Xie H

Wed Nov 23 00:00:00 UTC 2022

GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.

Experimental cell research

Wang D,Wei X,Chen X,Wang Q,Zhang J,Kalvakolanu DV,Guo B,Zhang L

Fri Oct 01 00:00:00 UTC 2021

GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.

Experimental cell research

Wang D,Wei X,Chen X,Wang Q,Zhang J,Kalvakolanu DV,Guo B,Zhang L

Fri Oct 01 00:00:00 UTC 2021

GRIM-19 deficiency promotes clear cell renal cell carcinoma progression and is associated with high TNM stage and Fuhrman grade.

Oncology letters

Yan N,Feng X,Jiang S,Sun W,Sun MZ,Liu S

Mon Jun 01 00:00:00 UTC 2020

GRIM-19 deficiency promotes clear cell renal cell carcinoma progression and is associated with high TNM stage and Fuhrman grade.

Oncology letters

Yan N,Feng X,Jiang S,Sun W,Sun MZ,Liu S

Mon Jun 01 00:00:00 UTC 2020

Clinical and molecular findings in a family expressing a novel heterozygous variant of the G elongation factor mitochondrial 1 gene.

Experimental and therapeutic medicine

Su C,Wang F

Tue Dec 01 00:00:00 UTC 2020

Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications.

Human gene therapy

Xu Y,Wang X,Guo B,Wang D,Kalvakolanu DV,Chen X,Tang J,Zhang L,Yang Q

Fri Nov 01 00:00:00 UTC 2019

Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications.

Human gene therapy

Xu Y,Wang X,Guo B,Wang D,Kalvakolanu DV,Chen X,Tang J,Zhang L,Yang Q

Fri Nov 01 00:00:00 UTC 2019

Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation.

Cancer chemotherapy and pharmacology

Ni F,Yan CY,Zhou S,Hui PY,Du YH,Zheng L,Yu J,Hu XJ,Zhang ZG

Mon Oct 01 00:00:00 UTC 2018

Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation.

Cancer chemotherapy and pharmacology

Ni F,Yan CY,Zhou S,Hui PY,Du YH,Zheng L,Yu J,Hu XJ,Zhang ZG

Mon Oct 01 00:00:00 UTC 2018

Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation.

Cancer chemotherapy and pharmacology

Ni F,Yan CY,Zhou S,Hui PY,Du YH,Zheng L,Yu J,Hu XJ,Zhang ZG

Mon Oct 01 00:00:00 UTC 2018

Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation.

Cancer chemotherapy and pharmacology

Ni F,Yan CY,Zhou S,Hui PY,Du YH,Zheng L,Yu J,Hu XJ,Zhang ZG

Mon Oct 01 00:00:00 UTC 2018

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.

International journal of oncology

Hu K,Tian Y,Du Y,Huang L,Chen J,Li N,Liu W,Liang Z,Zhao L

Sun May 01 00:00:00 UTC 2016

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.

International journal of oncology

Hu K,Tian Y,Du Y,Huang L,Chen J,Li N,Liu W,Liang Z,Zhao L

Sun May 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Cell d; Cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CI-B16.6; complex I B16.6 subunit; Complex I-B16.6; FLJ58045; FLJ59191; gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19; GRIM-19; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit

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Gene Aliases: 2700054G14Rik; AU022060; B16.6; CDA016; CGI-39; GRIM-19; GRIM19; NDUFA13

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UniProt ID: (Human) Q9P0J0, (Mouse) Q9ERS2

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Entrez Gene ID: (Rat) 100911483, (Human) 51079, (Mouse) 67184

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Function(s)

NADH dehydrogenase activity protein binding ATP binding NADH dehydrogenase (ubiquinone) activity dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

mitochondrial electron transport, NADH to ubiquinone positive regulation of peptidase activity negative regulation of cell growth mitochondrial respiratory chain complex I assembly cellular response to interferon-beta positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein import into mitochondrial inner membrane positive regulation of protein catabolic process negative regulation of transcription, DNA-templated cellular response to retinoic acid reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GRIM19 Polyclonal Antibody

GRIM19 Antibody (10986-1-AP) in IHC (P)

Product Details

10986-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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