MA5-15801 targets NR3C1 in FACS, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15801 immunogen is purified recombinant fragment of human NR3C1 expressed in E. Coli.
MA5-15801 detects NR3C1 which has a predicted molecular weight of approximately 86kDa.
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GCCR, GCR, GR, GRL, glucocorticoid nuclear receptor variant 1; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; glucocorticoid receptor 1; GR; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3 group C member 1 variant DL-1; nuclear receptor subfamily 3 group C member 1 variant NS-1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Aliases: GCCR; GCR; GCRST; GR; GRL; Grl-1; Grl1; NR3C1
UniProt ID: (Human) F5ATB7