A novel class II histone deacetylase, HDAC10 is most similar to HDAC6. Both contain a unique, putative second catalytic domain not found in other HDACs. In HDAC10, however, this domain is not functional. Unlike HDAC6, which is normally a cytoplasmic deacetylase, HDAC10 resides in both the nucleus and cytoplasm. Data suggests that HDAC10 may play roles both in the nucleus, as a transcriptional modulator, and in the cytoplasm in an unidentified role. HDAC10 variants seem present in certain cell lines and tissues that are as of yet not characterized.
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Protein Aliases: DKFZp761B039; HD10; Histone deacetylase 10; MGC149722; Polyamine deacetylase HDAC10; RP3-402G11.7
Gene Aliases: HD10; HDAC10
UniProt ID: (Human) Q969S8
Entrez Gene ID: (Human) 83933