HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
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Protein Aliases: HD2; hdac 2; hdac-2; Histone deacetylase 2; transcriptional regulator homolog RPD3; YY1-associated factor 1
Gene Aliases: HD2; HDAC2; RPD3; YAF1
UniProt ID: (Human) Q92769
Entrez Gene ID: (Human) 3066