|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant rat c-erbB-3/HER-3 oncoprotein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||1 µg/mL|
MA5-13037 targets HER-3 in IP and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-13037 immunogen is recombinant rat c-erbB-3/HER-3 oncoprotein.
c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination.
MA5-13037 was used in immunoprecipitation and western blot to study the requirement of Nrdp1 E3 ubiquitin ligase oligomer formation for self-ubiquitinylation by not for the unbiquitinylation of erbB3
|Printsev I,Yen L,Sweeney C,Carraway KL||The Journal of biological chemistry (289:8570)||2014|
The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2.
MA5-13037 was used in western blot to investigate the effect of the constitutive activity of EGFRvIII on wild-type EGFR and erbB2 in OVCA 433 cells
|Zeineldin R,Ning Y,Hudson LG||The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (58:529)||2010|
Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells.
MA5-13037 was used in western blot to study the mechanism of Bmx/Etk activation in prostate cancer cells
|Jiang X,Borgesi RA,McKnight NC,Kaur R,Carpenter CL,Balk SP||The Journal of biological chemistry (282:32689)||2007|
The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells.
MA5-13037 was used in western blot to investigate the role of ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells
|Liu W,Zscheppang K,Murray S,Nielsen HC,Dammann CE||Biochimica et biophysica acta (1772:737)||2007|
ErbB receptor dimerization, localization, and co-localization in mouse lung type II epithelial cells.
MA5-13037 was used in western blot to study erbB receptor dimerization, localization, and co-localization in mouse lung type II epithelial cells
|Zscheppang K,Korenbaum E,Bueter W,Ramadurai SM,Nielsen HC,Dammann CE||Pediatric pulmonology (41:1205)||2006|
HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer.
MA5-13037 was used in immunohistochemistry to identify multiple subtypes of HER2-positive metastatic breast cancer based on the quantitative expression analysis of HER3, p95HER2 and HER2 protein levels
|Lipton A,Goodman L,Leitzel K,Cook J,Sperinde J,Haddad M,Köstler WJ,Huang W,Weidler JM,Ali S,Newton A,Fuchs EM,Paquet A,Singer CF,Horvat R,Jin X,Banerjee J,Mukherjee A,Tan Y,Shi Y,Chenna A,Larson J,Lie Y,Sherwood T,Petropoulos CJ,Williams S,Winslow J,Parry G,Bates M||Breast cancer research and treatment (141:43)||2013|
ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells.
MA5-13037 was used in immunocytochemistry and western blot to study the role of ErbB4 in regulating fetal surfactant phospholipid synthesis in primary fetal rat type II cells
|Zscheppang K,Liu W,Volpe MV,Nielsen HC,Dammann CE||American journal of physiology. Lung cellular and molecular physiology (293:L429)||2007|
avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; c-erbB-3; c-erbB3; glial growth factor receptor; human epidermal growth factor receptor 3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
c-erbB-3; c-erbB3; C76256; ErbB-3; ERBB3; erbB3-S; Erbb3r; HER3; LCCS2; MDA-BF-1; nuc-ErbB3; p180-ErbB3; p45-sErbB3; p85-sErbB3