Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
NeoBiotechnologies
Antibody is stable for 24 months.
Positive Control: Daudi, Raji or U266 cells. Human lymphocytes. Human lymph node, tonsil or testis. Cellular Localization: Cytoplasm. Cell membrane.
Specificity Comments: Recognizes a protein of kDa, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).
GCET2 is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GCET2 germinal center expressed transcript 2; Germinal center associated lymphoma (hGAL); Germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2; Germinal center-associated lymphoma protein; Germinal center-associated signaling and motility protein; germinal center-associated, signaling and motility; hGAL; human germinal center-associated lymphoma; MGC40441
Gene Aliases: GAL; GCAT2; GCET2; GCSAM; HGAL
UniProt ID: (Human) Q8N6F7
Entrez Gene ID: (Human) 257144
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