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Abnova

HHEX Monoclonal Antibody (1A5)

View all (31) Hex antibodies
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Product Details

H00003087-M02

Applications Tested Dilution Publications

Western Blot (WB)

 1-5 µg/mL -

ELISA (ELISA)

 0.3 ng/mL -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Mouse / IgG2a, lambda

Class

 Monoclonal

Type

 Antibody

Clone

 1A5

Immunogen

HHEX (AAH14336, 1 a.a. approximately 270 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 See Label

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.4

Contains

 no preservative

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: MQYPHPGPAA GAVGVPLYAP TPLLQPAHPT PFYIEDILGR GPAAPTPAPT LPSPNSSFTS LVSPYRTPVY EPTPIHPAFS HHSAAALAAA YGPGGFGGPL YPFPRTVNDY THALLRHDPL GKPLLWSPFL QRPLHKRKGG QVRFSNDQTI ELEKKFETQK YLSPPERKRL TKMLQLSERQ VKTWFQNRRA KWRRLKQENP QSNKKEELES LDSSCDQRQD LPSEQNKGAS LDSSQCSPSP ASQEDLESEI SEDSDQEVDI EGDKSYFNAG

Target Information

HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hematopoietically-expressed homeobox protein HHEX; homeobox; Homeobox protein HEX; Homeobox protein PRH; homeobox, hematopoietically expressed; proline-rich homeodomain-containing transcription factor

Gene Aliases: HEX; HHEX; HMPH; HOX11L-PEN; PRH; PRHX

UniProt ID: (Human) Q03014

Entrez Gene ID: (Human) 3087

Molecular Function: homeodomain transcription factor

Function(s)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis in utero embryonic development myeloid leukocyte differentiation transcription, DNA-templated mRNA export from nucleus Notch signaling pathway endoderm development cell proliferation anterior/posterior pattern specification negative regulation of transcription by transcription factor localization negative regulation of transcription by competitive promoter binding Wnt signaling pathway negative regulation of angiogenesis poly(A)+ mRNA export from nucleus interkinetic nuclear migration cell differentiation positive regulation of Wnt signaling pathway B cell differentiation thyroid gland development negative regulation of vascular endothelial growth factor receptor signaling pathway pancreas development protein localization to nucleus embryonic heart tube development multicellular organism growth regulation of cell proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter forebrain morphogenesis primary lung bud formation gall bladder development hepatic duct development hepatoblast differentiation hepatocyte differentiation DNA conformation change primitive streak formation
Process(es)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein binding transcription factor binding eukaryotic initiation factor 4E binding DNA binding, bending TBP-class protein binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding HMG box domain binding

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