|Tested species reactivity||Human, Pig|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Burkitt's lymphoma cell line Raji.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 3 publications below|
HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors.
MA1-19145 was used in flow cytometry to characterize human splenic dendritic cells.
|McIlroy D,Troadec C,Grassi F,Samri A,Barrou B,Autran B,Debré P,Feuillard J,Hosmalin A||Blood (97:3470)||2001|
Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects.
MA1-19145 was used in flow cytometry to test if recombinant human interferon-gamma enhancing clearance of microbes in patients with chronic granulomatous disease.
|Schiff DE,Rae J,Martin TR,Davis BH,Curnutte JT||Blood (90:3187)||1997|
Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.
MA1-19145 was used in flow cytometry to describe the cellular changes that IFN beta-1b treatment induced in the experimental autoimmune encephalomyelitis model.
|Genç K,Dona DL,Reder AT||The Journal of clinical investigation (99:2664)||1997|