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PA1-22173 detects Histone H2B in Human and mammal samples.
PA1-22173 has been successfully used in ELISA, Immunofluorescence, Immunoprecipitation and Western Blot procedures. Precicted molecular weight is 15 kDa.
PA1-22173 immunogen is an Ovalbumin-conjugated peptide corresponding to residues 1-22 of mammalian H2B (acetyl lysine at positions 5,12,15,20).
Store at 4ºC short term. For long term storage, aliquot and store at -20ºC, avoiding freeze/thaw cycles.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The nucleosomes wrap further and compact DNA into chromotin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones play a central role in transciption regulation, DNA repair, DNA replication, and chromosomal stability. H2B has a broad antibacterial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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