|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable, Rhesus monkey|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human IL-4.|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is recommended as a capture antibody in Sandwich ELISA applications.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Antipsychotic drugs suppress the AKT/NF-¿B pathway and regulate the differentiation of T-cell subsets.
AHC0642 was used in blocking assay to examine how antipsychotic drugs affect immune responses.
|Chen ML,Tsai TC,Lin YY,Tsai YM,Wang LK,Lee MC,Tsai FM||Immunology letters (140:81)||2011|
|Rhesus monkey||Not Cited||
Phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived NKT cells.
AHC0642 was used in flow cytometry to describe the phenotype and function of Valpha24(+) splenic T cells from rhesus macaques.
|Gansuvd B,Hubbard WJ,Hutchings A,Thomas FT,Goodwin J,Wilson SB,Exley MA,Thomas JM||Journal of immunology (Baltimore, Md. : 1950) (171:2904)||2003|
Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines.
AHC0642 was used in flow cytometry to report an in vitro differentiation assay in which human naive CD4(+) cells are driven toward either the Th1 or Th2 phenotype and study them.
|Cousins DJ,Lee TH,Staynov DZ||Journal of immunology (Baltimore, Md. : 1950) (169:2498)||2002|
|Not Applicable||Not Cited||
Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells.
AHC0642 was used in ELISA to compare the ability of plasmacytoid dendritic cells and monocyte-derived dendritic cells to activate T cells
|Janke M,Witsch EJ,Mages HW,Hutloff A,Kroczek RA||Immunology (118:353)||2006|
|Not Applicable||1 µg/ml||
Insulin-like growth factor-I stimulates IL-10 production in human T cells.
AHC0642 was used in ELISA to explore the immunomodulatory effects of insulin-like growth factor through regulation of cytokine production
|Kooijman R,Coppens A||Journal of leukocyte biology (76:862)||2004|
Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production.
AHC0642 was used in ELISA to examine the effects of co-stimulation by CD58 on the production of Th1-type or Th2 type cytokines.
|Bullens DM,Rafiq K,Charitidou L,Peng X,Kasran A,Warmerdam PA,Van Gool SW,Ceuppens JL||International immunology (13:181)||2001|