Invitrogen

IL23R Polyclonal Antibody

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IL23R Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemichal analysis of IL23R in MCF-7 cells using a Polyclonal antibody (Product # PA5-113004) at a dilution of 1:100. An Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibdoy was used.

IL23R Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunocytochemical analysis of paraffin-embeded IL23R in human kidney tissue using a IL23R Polyclonal antibody (Product # PA5-113004) at a dilution of 1:100.

IL23R Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunocytochemical analysis of paraffin-embeded IL23R in human tonsil tissue using a IL23R Polyclonal antibody (Product # PA5-113004) at a dilution of 1:100.

IL23R Antibody in Western Blot (WB) — Western Blot analysis of IL23R in multiple sample types using a IL23R polyclonal antibody (Product # PA5-113004) at a concentration of 3.4 µg/ml. A goat anti rabbit polyclonal secondary antibody was used at a dilution of 1:50,000. Sample types that were tested include: NIH/3T3 whole cell lysate, K562 whole cell lysate, Mouse liver tissue, Mouse lung tissue, Mouse spleen tissue .

Product Details

PA5-113004

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:5,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:50-1:200	-
ELISA (ELISA)	Assay-dependent	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant Human Interleukin-23 receptor protein (15-125AA) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	5 mg/mL
Purification	Protein G
Storage buffer	PBS, pH 7.4, with 50% glycerol
Contains	0.03% ProClin 300
Storage conditions	-20°C or -80°C if preferred
RRID	AB_2867738

Target Information

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: IBD17; IL 23R; IL-23 receptor; Interleukin-23 receptor

Gene Aliases: IL-23R; IL23R

UniProt ID: (Human) Q5VWK5, (Mouse) Q8K4B4

Entrez Gene ID: (Human) 149233, (Mouse) 209590

Molecular Function: transmembrane signal receptor

positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response inflammatory response positive regulation of activation of JAK2 kinase activity response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation response to interferon-gamma interleukin-23-mediated signaling pathway positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat4 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of memory T cell differentiation positive regulation of osteoclast differentiation defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment immune system process leukocyte mediated immunity JAK-STAT cascade cytokine-mediated signaling pathway innate immune response

Process(es)

interleukin-12 receptor binding protein binding interleukin-23 binding interleukin-23 receptor activity