In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha, rhIL-2 R beta, rhIL-15 R alpha, recombinant mouse IL-2 R gamma, or recombinant canine IL-2 R alpha is observed. In Western blots, approximately 80% cross-reactivity with recombinant human IL-2 R beta, 50% cross-reactivity with rhIL-15 R alpha and recombinant mouse IL-2 R alpha, and no cross-reactivity with rhIL-2 R alpha is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
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Protein Aliases: CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; Cytokine receptor common subunit gamma; gamma (c); gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2R gamma; IL2RG; IMD4; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; P64; SCIDX; SCIDX1
Gene Aliases: CD132; CIDX; IL-2RG; IL2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785
Entrez Gene ID: (Human) 3561